N-Desmethyltamoxifen hydrochloride

• CAT Number: R001331
• CAS Number: 15917-65-4
• Molecular Formula: C25H28ClNO
• Molecular Weight: 393.95
• Purity: ≥95%
• IUPAC Name: 2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]-N-methylethanamine;hydrochloride
• InChI: InChI=1S/C25H27NO.ClH/c1-3-24(20-10-6-4-7-11-20)25(21-12-8-5-9-13-21)22-14-16-23(17-15-22)27-19-18-26-2;/h4-17,26H,3,18-19H2,1-2H3;1H/b25-24-
• InChIKey: GMLHJWZEYLTNJW-BJFQDICYSA-N
• SMILES: CC/C(=C(\C1=CC=CC=C1)/C2=CC=C(C=C2)OCCNC)/C3=CC=CC=C3.Cl

N-Desmethyltamoxifen hydrochloride(CAT: R001331) is the primary active metabolite of tamoxifen, a selective estrogen receptor modulator (SERM) widely used in breast cancer therapy. Formed through CYP3A4/5-mediated metabolism, it retains significant affinity for estrogen receptors (ER), contributing to the anti-estrogenic and partial agonist effects of tamoxifen. This metabolite plays a critical role in modulating estrogen signaling in hormone-dependent cancers and serves as a reference standard in pharmacokinetic, metabolism, and drug interaction studies. Supplied as the hydrochloride salt, N-Desmethyltamoxifen is an essential research compound for oncology, endocrinology, and drug metabolism investigations.