For research use only. Not for therapeutic Use.
N-Desmethyl Pimavanserin(CAT: I017318) is the major active metabolite of Pimavanserin, a selective 5-HT2A receptor inverse agonist/antagonist approved for the treatment of Parkinson’s disease psychosis. This metabolite retains high affinity for the serotonin 5-HT2A receptor and contributes significantly to the pharmacological activity of Pimavanserin. N-Desmethyl Pimavanserin is widely used as a reference standard in pharmacokinetic, metabolic, and bioanalytical studies, enabling detailed evaluation of drug metabolism, receptor binding, and therapeutic exposure. Its characterization is critical for advancing research in neurological and psychiatric disorders, particularly in the fields of psychosis, Parkinson’s disease, and dementia-related behavioral symptoms.
| CAS Number | 639863-77-7 |
| Synonyms | 1-[(4-fluorophenyl)methyl]-3-[[4-(2-methylpropoxy)phenyl]methyl]-1-piperidin-4-ylurea |
| Molecular Formula | C24H32FN3O2 |
| Purity | ≥95% |
| IUPAC Name | 1-[(4-fluorophenyl)methyl]-3-[[4-(2-methylpropoxy)phenyl]methyl]-1-piperidin-4-ylurea |
| InChI | InChI=1S/C24H32FN3O2/c1-18(2)17-30-23-9-5-19(6-10-23)15-27-24(29)28(22-11-13-26-14-12-22)16-20-3-7-21(25)8-4-20/h3-10,18,22,26H,11-17H2,1-2H3,(H,27,29) |
| InChIKey | CJAUQHPXNICIJI-UHFFFAOYSA-N |
| SMILES | CC(C)COC1=CC=C(C=C1)CNC(=O)N(CC2=CC=C(C=C2)F)C3CCNCC3 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
