N-Desmethyl Galanthamine

• CAT Number: R003441
• CAS Number: 41303-74-6
• Molecular Formula: C16H19NO3
• Molecular Weight: 273.33
• Purity: ≥95%
• Synonyms: (1S,12S,14R)-9-methoxy-11-oxa-4-azatetracyclo[8.6.1.01,12.06,17]heptadeca-6(17),7,9,15-tetraen-14-ol
• InChI: InChI=1S/C16H19NO3/c1-19-12-3-2-10-9-17-7-6-16-5-4-11(18)8-13(16)20-15(12)14(10)16/h2-5,11,13,17-18H,6-9H2,1H3/t11-,13-,16-/m0/s1
• InChIKey: AIXQQSTVOSFSMO-RBOXIYTFSA-N
• SMILES: COC1=C2C3=C(CNCC[C@]34C=C[C@@H](C[C@@H]4O2)O)C=C1

N-Desmethyl galanthamine（Cat No.:R003441）is a naturally derived alkaloid and a demethylated analog of galanthamine, found in plants like Galanthus and Lycoris species. It functions as a reversible acetylcholinesterase inhibitor and allosteric modulator of nicotinic acetylcholine receptors, enhancing cholinergic neurotransmission. This makes it a compound of interest in neurodegenerative disease research, particularly for Alzheimer’s disease. Compared to galanthamine, N-desmethyl galanthamine may exhibit different pharmacokinetics or receptor affinities, offering potential advantages in drug development. It serves as both a valuable pharmacological probe and a lead structure for designing novel cognitive enhancers.