For research use only. Not for therapeutic Use.
N-Desmethyl-Apalutamide(CAT: I017324) is the primary active metabolite of Apalutamide, a next-generation androgen receptor (AR) antagonist approved for the treatment of non-metastatic and metastatic castration-resistant prostate cancer (CRPC). Retaining strong AR binding and inhibitory activity, this metabolite significantly contributes to the overall pharmacological effect of Apalutamide. It is widely used as a reference standard in pharmacokinetic, metabolic, and bioanalytical studies, particularly in evaluating drug exposure, metabolic pathways, and therapeutic response. As a key metabolite, N-Desmethyl-Apalutamide is a valuable tool in oncology research, prostate cancer drug development, and clinical pharmacology.
| CAS Number | 1332391-11-3 |
| Synonyms | 4-[7-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-8-oxo-6-sulfanylidene-5,7-diazaspiro[3.4]octan-5-yl]-2-fluorobenzamide |
| Molecular Formula | C20H13F4N5O2S |
| Purity | ≥95% |
| IUPAC Name | 4-[7-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-8-oxo-6-sulfanylidene-5,7-diazaspiro[3.4]octan-5-yl]-2-fluorobenzamide |
| InChI | InChI=1S/C20H13F4N5O2S/c21-14-7-10(2-3-12(14)16(26)30)29-18(32)28(17(31)19(29)4-1-5-19)11-6-13(20(22,23)24)15(8-25)27-9-11/h2-3,6-7,9H,1,4-5H2,(H2,26,30) |
| InChIKey | BAANHOAPFBHUDX-UHFFFAOYSA-N |
| SMILES | C1CC2(C1)C(=O)N(C(=S)N2C3=CC(=C(C=C3)C(=O)N)F)C4=CC(=C(N=C4)C#N)C(F)(F)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
