N-Desethyl Sunitinib hydrochloride

• CAT Number: I044470
• CAS Number: 1261432-05-6
• Molecular Formula: C20H24ClFN4O2
• Molecular Weight: 406.88
• Purity: ≥95%
• Synonyms: N-[2-(ethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide;hydrochloride
• InChI: InChI=1S/C20H23FN4O2.ClH/c1-4-22-7-8-23-20(27)18-11(2)17(24-12(18)3)10-15-14-9-13(21)5-6-16(14)25-19(15)26;/h5-6,9-10,22,24H,4,7-8H2,1-3H3,(H,23,27)(H,25,26);1H/b15-10-
• InChIKey: WJMIVJQUMZPBDC-AZJSCORLSA-N
• SMILES: CCNCCNC(=O)C1=C(NC(=C1C)/C=C\2/C3=C(C=CC(=C3)F)NC2=O)C.Cl

N-Desethyl Sunitinib hydrochloride（Cat No.:I044470）is the active metabolite of sunitinib, a multi-targeted receptor tyrosine kinase inhibitor used in cancer therapy. It retains potent inhibitory activity against key kinases such as VEGFR, PDGFR, KIT, and FLT3, which are involved in angiogenesis, tumor growth, and metastasis. The N-desethyl modification improves its pharmacokinetic profile and contributes significantly to the therapeutic effects of sunitinib in vivo. The hydrochloride salt enhances solubility and stability for research applications. This compound is widely used in oncology research to study kinase signaling and drug metabolism.