N-Desethyl Metoclopramide

• CAT Number: R053855
• CAS Number: 27260-19-1
• Molecular Formula: C12H18ClN3O2
• Molecular Weight: 271.75
• Purity: ≥95%
• Synonyms: 4-Amino-5-chloro-N-[2-(ethylamino)ethyl]-2-methoxybenzamide; 4-Amino-5-chloro-N-[2-(ethylamino)ethyl]-o-anisamide; N-(Ethylaminoethyl)-2-methoxy-4-amino-5-chlorobenzamide
• Storage: -20°C
• IUPAC Name: 4-amino-5-chloro-N-[2-(ethylamino)ethyl]-2-methoxybenzamide
• InChI: InChI=1S/C12H18ClN3O2/c1-3-15-4-5-16-12(17)8-6-9(13)10(14)7-11(8)18-2/h6-7,15H,3-5,14H2,1-2H3,(H,16,17)
• InChIKey: RTQMQUZXBADBGJ-UHFFFAOYSA-N
• SMILES: CCNCCNC(=O)C1=CC(=C(C=C1OC)N)Cl

N-Desethyl metoclopramide (Cat No.: R053855) is a metabolite of metoclopramide, a dopamine D₂ receptor antagonist used primarily as an antiemetic and prokinetic agent. In this compound, the ethyl group on the nitrogen atom of the original metoclopramide molecule is removed, altering its pharmacokinetic and pharmacodynamic profile. N-Desethyl metoclopramide retains partial activity and may contribute to the drug’s overall therapeutic or side effect profile. It is studied in drug metabolism and pharmacology for its role in understanding metoclopramide’s biotransformation and systemic effects.