N-Boc-dolaproine-OH ((+)-phenylethylamine)

• CAT Number: I040263
• Molecular Formula: C21H34N2O5
• Molecular Weight: 394.51
• Purity: ≥95%
• Synonyms: (2R,3R)-3-hydroxy-2-methyl-3-[(2S)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidin-2-yl]propanoic acid;(1R)-1-phenylethanamine
• InChI: InChI=1S/C13H23NO5.C8H11N/c1-8(11(16)17)10(15)9-6-5-7-14(9)12(18)19-13(2,3)4;1-7(9)8-5-3-2-4-6-8/h8-10,15H,5-7H2,1-4H3,(H,16,17);2-7H,9H2,1H3/t8-,9+,10-;7-/m11/s1
• InChIKey: MKHGXLKYSRPUEW-PSVJOJMUSA-N
• SMILES: CC(C1=CC=CC=C1)N.CC(C(C1CCCN1C(=O)OC(C)(C)C)O)C(=O)O

N-Boc-dolaproine-OH ((+)-phenylethylamine)(CAT: I040263) is a synthetic derivative of dolaproine, a unique amino acid residue found in the marine-derived cytotoxic pentapeptide Dolastatin 10 (HY-15580). This compound retains the structural features critical for bioactivity, including a Boc-protected hydroxylated pyrrolidine ring, and serves as a key building block in the synthesis of Dolastatin analogs and antibody-drug conjugates (ADCs). Dolastatin 10 and its derivatives exhibit potent anticancer activity by inhibiting tubulin polymerization and mitotic progression. N-Boc-dolaproine-OH is ideal for use in peptide synthesis, medicinal chemistry, and cytotoxic payload development.