N-Boc-dolaproine-methyl

• CAT Number: I040496
• CAS Number: 164456-57-9
• Molecular Formula: C14H25NO5
• Molecular Weight: 287.35
• Purity: ≥95%
• Synonyms: tert-butyl (2S)-2-[(1R,2R)-1-hydroxy-3-methoxy-2-methyl-3-oxopropyl]pyrrolidine-1-carboxylate
• InChI: InChI=1S/C14H25NO5/c1-9(12(17)19-5)11(16)10-7-6-8-15(10)13(18)20-14(2,3)4/h9-11,16H,6-8H2,1-5H3/t9-,10+,11-/m1/s1
• InChIKey: YESVEVMVKPHDFA-OUAUKWLOSA-N
• SMILES: CC(C(C1CCCN1C(=O)OC(C)(C)C)O)C(=O)OC

N-Boc-dolaproine-methyl(CAT: I040496) is a protected derivative of dolaproine, a non-proteinogenic amino acid found in the cytotoxic marine-derived pentapeptide Dolastatin 10 (HY-15580). As a key structural component, dolaproine contributes to Dolastatin 10’s ability to inhibit tubulin polymerization and disrupt mitosis, resulting in potent anticancer activity. The N-Boc group protects the amino functionality, while the methyl ester enhances synthetic versatility for peptide coupling in medicinal chemistry applications. N-Boc-dolaproine-methyl is ideal for use in the synthesis of peptide-based therapeutics, including analogs of Dolastatin 10 and antibody-drug conjugates (ADCs). Supplied in high purity, it supports advanced oncology and peptide drug development research.