N-Boc-dolaproine-amide-Me-Phe

• CAT Number: I040259
• CAS Number: 3026596-72-2
• Molecular Formula: C23H36N2O4
• Molecular Weight: 404.54
• Purity: ≥95%
• Synonyms: tert-butyl (2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(2S)-1-phenylpropan-2-yl]amino]propyl]pyrrolidine-1-carboxylate
• InChI: InChI=1S/C23H36N2O4/c1-16(15-18-11-8-7-9-12-18)24-21(26)17(2)20(28-6)19-13-10-14-25(19)22(27)29-23(3,4)5/h7-9,11-12,16-17,19-20H,10,13-15H2,1-6H3,(H,24,26)/t16-,17+,19-,20+/m0/s1
• InChIKey: BNKYTSFNYISCMT-KVPLUYHFSA-N
• SMILES: CC(CC1=CC=CC=C1)NC(=O)C(C)C(C2CCCN2C(=O)OC(C)(C)C)OC

N-Boc-dolaproine-amide-Me-Phe(CAT: I040259) is a synthetic amino acid derivative representing a key structural residue of Dolastatin 10 (HY-15580), a potent cytotoxic pentapeptide known for its ability to inhibit tubulin polymerization and disrupt mitosis. As part of the Dolastatin 10 framework, this fragment contributes to the compound’s strong anticancer properties, particularly its microtubule-targeting activity. N-Boc-dolaproine-amide-Me-Phe is valuable for researchers engaged in peptide-based drug design, structure–activity relationship (SAR) studies, and the development of novel antimitotic agents. It serves as an essential building block for reconstructing or modifying cytotoxic peptide scaffolds in cancer research and therapeutic development.