N-(Azido-PEG3)-N-(PEG2-amine)-PEG3-acid

• CAT Number: I014503
• CAS Number: 2183440-70-0
• Molecular Formula: C24H47N5O11
• Molecular Weight: 581.66
• Purity: ≥95%
• Synonyms: 3-[2-[2-[2-[3-[2-(2-aminoethoxy)ethoxy]propanoyl-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]amino]ethoxy]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C24H47N5O11/c25-3-9-35-15-13-33-7-1-23(30)29(5-11-37-17-21-39-19-14-34-8-2-24(31)32)6-12-38-18-22-40-20-16-36-10-4-27-28-26/h1-22,25H2,(H,31,32)
• InChIKey: FZLMDRGRFLPQRO-UHFFFAOYSA-N
• SMILES: C(COCCOCCN)C(=O)N(CCOCCOCCOCCC(=O)O)CCOCCOCCOCCN=[N+]=[N-]

N-(Azido-PEG3)-N-(PEG2-amine)-PEG3-acid（Cat No.:I014503）is a multifunctional PEG-based linker integrating three distinct reactive groups: an azide, a primary amine, and a terminal carboxylic acid. The azide allows copper-catalyzed or copper-free click reactions with alkynes, while the amine reacts readily with activated esters or carboxyl groups to form stable amide bonds. The carboxylic acid provides an additional handle for conjugation via carbodiimide chemistry. The PEG spacers (PEG3 and PEG2) improve solubility, flexibility, and minimize steric hindrance. This reagent is highly versatile for orthogonal bioconjugation, drug conjugates, probe development, and biomaterials engineering.