N-Acetyl-L-carnosine

• CAT Number: R002543
• CAS Number: 56353-15-2
• Molecular Formula: C11H16N4O4
• Molecular Weight: 268.27
• Purity: ≥95%
• Synonyms: NAC, N-α-Acetyl-N-β-alanyl-L-histidine; N-Acetylcarnosine
• Target: Peptide and Derivatives
• Storage: -20°C
• IUPAC Name: (2S)-2-(3-acetamidopropanoylamino)-3-(1H-imidazol-5-yl)propanoic acid
• InChI: InChI=1S/C11H16N4O4/c1-7(16)13-3-2-10(17)15-9(11(18)19)4-8-5-12-6-14-8/h5-6,9H,2-4H2,1H3,(H,12,14)(H,13,16)(H,15,17)(H,18,19)/t9-/m0/s1
• InChIKey: BKAYIFDRRZZKNF-VIFPVBQESA-N
• SMILES: CC(=O)NCCC(=O)NC(CC1=CN=CN1)C(=O)O

N-Acetyl-L-carnosine (CAT: R002543) is a naturally occurring dipeptide derivative composed of N-acetylated L-carnosine, which itself consists of β-alanine and L-histidine. The acetylation improves its stability and bioavailability compared to unmodified carnosine, enhancing its potential as a therapeutic agent. NALC is best known for its antioxidant, anti-glycation, and anti-lipid peroxidation properties, making it valuable in protecting proteins, lipids, and DNA from oxidative damage. It is widely studied in ophthalmology, particularly in eye drop formulations for the prevention and treatment of cataracts, oxidative stress–related eye disorders, and age-related vision decline.