MTX115325

• CAT Number: I040512
• CAS Number: 2750895-97-5
• Molecular Formula: C18H16N6O2
• Molecular Weight: 348.36
• Purity: ≥95%
• Synonyms: (3aR,4R,6aR)-1-[5-(2-cyanopyridin-4-yl)-1,3-oxazole-2-carbonyl]-4-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrole-5-carbonitrile
• InChI: InChI=1S/C18H16N6O2/c1-11-14-3-5-24(15(14)9-23(11)10-20)18(25)17-22-8-16(26-17)12-2-4-21-13(6-12)7-19/h2,4,6,8,11,14-15H,3,5,9H2,1H3/t11-,14-,15+/m1/s1
• InChIKey: LBHXWJUYDOSAAH-DFBGVHRSSA-N
• SMILES: CC1C2CCN(C2CN1C#N)C(=O)C3=NC=C(O3)C4=CC(=NC=C4)C#N

MTX115325 (CAT: I040512) is a potent, orally active USP30 inhibitor (IC₅₀ = 12 nM) with demonstrated brain penetration and neuroprotective effects. It enhances ubiquitination of the mitochondrial outer membrane protein TOM20 (EC₅₀ = 32 nM), promoting mitophagy and mitochondrial quality control. MTX115325 prevents dopaminergic neuron loss, preserves striatal dopamine, and reduces astrocyte activation in AAV-A53T-SNCA mouse models. It shows excellent oral bioavailability (98%) and favorable CNS distribution (Kpu,u ≈ 0.4). Effective in vitro (10–1000 nM), it increases TOM20 ubiquitination and mitophagy in SH-SY5Y and HeLa cells. Supplied in high purity for neurodegeneration, Parkinson’s disease, and autophagy research.

Reference

MTX115325 (Example 1) is a potent, orally active USP30 inhibitor (IC₅₀ = 12 nM) with demonstrated brain penetration and neuroprotective effects. It enhances ubiquitination of the mitochondrial outer membrane protein TOM20 (EC₅₀ = 32 nM), promoting mitophagy and mitochondrial quality control. MTX115325 prevents dopaminergic neuron loss, preserves striatal dopamine, and reduces astrocyte activation in AAV-A53T-SNCA mouse models. It shows excellent oral bioavailability (98%) and favorable CNS distribution (Kpu,u ≈ 0.4). Effective in vitro (10–1000 nM), it increases TOM20 ubiquitination and mitophagy in SH-SY5Y and HeLa cells. Supplied in high purity for neurodegeneration, Parkinson’s disease, and autophagy research.