MTL-CEBPA sodium

• CAT Number: I040332
• Molecular Weight: 14410.00
• Purity: ≥95%

MTL-CEBPA (sodium)(CAT: I040332) is the sodium salt form of MTL-CEBPA (HY-132607), a small activating RNA (saRNA) specifically designed to upregulate the expression of CCAAT/enhancer-binding protein alpha (C/EBPα), a key transcription factor involved in cell differentiation, inflammation regulation, and tumor suppression. By enhancing C/EBPα expression, MTL-CEBPA (sodium) exerts notable anti-inflammatory and anti-cancer effects, particularly in hepatocellular carcinoma and myeloid-derived immune dysfunction. Its mechanism supports reprogramming of tumor-associated myeloid cells and restoration of normal gene expression patterns. MTL-CEBPA (sodium) is a valuable tool for epigenetic modulation and RNA-based therapeutic research.

Reference

[1]. Jiehua Zhou, et al.  Anti-inflammatory Activity of MTL-CEBPA, a Small Activating RNA Drug, in LPS-Stimulated Monocytes and Humanized Mice. Mol Ther. 2019 May 8;27(5):999-1016.
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