For research use only. Not for therapeutic Use.
MTI-31（Cat No.:I032847）is a selective and potent inhibitor of mitochondrial complex I, a key enzyme in the electron transport chain critical for cellular energy production. By targeting complex I, MTI-31 disrupts oxidative phosphorylation, reducing ATP generation and increasing reactive oxygen species, which can selectively impair cancer cells that rely heavily on mitochondrial metabolism. Preclinical studies have demonstrated its antitumor activity, particularly in cancers exhibiting metabolic vulnerabilities, such as MYC-driven or oxidative phosphorylation-dependent tumors. MTI-31 represents a promising metabolic therapy candidate aimed at exploiting mitochondrial dysfunction in oncology.
| CAS Number | 1567915-38-1 |
| Synonyms | N-methyl-3-[2-[(3S)-3-methylmorpholin-4-yl]-4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)pyrido[2,3-d]pyrimidin-7-yl]benzamide |
| Molecular Formula | C26H30N6O3 |
| Purity | ≥95% |
| IUPAC Name | N-methyl-3-[2-[(3S)-3-methylmorpholin-4-yl]-4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)pyrido[2,3-d]pyrimidin-7-yl]benzamide |
| InChI | InChI=1S/C26H30N6O3/c1-16-13-34-11-10-31(16)26-29-23-21(24(30-26)32-19-6-7-20(32)15-35-14-19)8-9-22(28-23)17-4-3-5-18(12-17)25(33)27-2/h3-5,8-9,12,16,19-20H,6-7,10-11,13-15H2,1-2H3,(H,27,33)/t16-,19?,20?/m0/s1 |
| InChIKey | LVPBYQVQBZLDAU-DZIBYMRMSA-N |
| SMILES | C[C@H]1COCCN1C2=NC3=C(C=CC(=N3)C4=CC(=CC=C4)C(=O)NC)C(=N2)N5C6CCC5COC6 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
