MST-312

• CAT Number: I045540
• CAS Number: 368449-04-1
• Molecular Formula: C20H16N2O6
• Molecular Weight: 380.35
• Purity: ≥95%
• Synonyms: N-[3-[(2,3-dihydroxybenzoyl)amino]phenyl]-2,3-dihydroxybenzamide
• InChI: InChI=1S/C20H16N2O6/c23-15-8-2-6-13(17(15)25)19(27)21-11-4-1-5-12(10-11)22-20(28)14-7-3-9-16(24)18(14)26/h1-10,23-26H,(H,21,27)(H,22,28)
• InChIKey: MIQUEZGHEJGPJB-UHFFFAOYSA-N
• SMILES: C1=CC(=CC(=C1)NC(=O)C2=C(C(=CC=C2)O)O)NC(=O)C3=C(C(=CC=C3)O)O

MST-312 (Cat No.: I045540) is a synthetic telomerase inhibitor derived from the epigallocatechin gallate (EGCG) scaffold. It suppresses telomerase activity, leading to progressive telomere shortening and growth inhibition in cancer cells. MST-312 has demonstrated antiproliferative effects across various tumor models, including breast and hematological cancers. Beyond telomerase inhibition, it can induce apoptosis, cell cycle arrest, and DNA damage responses. Widely used in oncology research, MST-312 provides a valuable tool for exploring telomere biology, cancer therapeutics, and mechanisms of tumor cell immortality.

Reference

[1]. Ameri Z, et al. Telomerase inhibitor MST-312 induces apoptosis of multiple myeloma cells and down-regulation of anti-apoptotic, proliferative and inflammatory genes. Life Sci. 2019;228:66-71.
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