For research use only. Not for therapeutic Use.
MSI-1436 lactate(CAT: I020475) is a selective, non-competitive inhibitor of protein-tyrosine phosphatase 1B (PTP1B), exhibiting an IC₅₀ of 1 μM and a 200-fold selectivity over T-cell protein tyrosine phosphatase (TCPTP), for which the IC₅₀ is 224 μM. By targeting PTP1B, a key negative regulator of insulin and leptin signaling, MSI-1436 lactate enhances insulin sensitivity and promotes energy balance, making it a promising candidate for metabolic disorder research, including type 2 diabetes and obesity. Its non-competitive inhibition mechanism ensures sustained enzyme blockade without directly competing with the substrate, and its high selectivity minimizes off-target effects, increasing its therapeutic potential in metabolic and endocrine studies.
| CAS Number | 1309370-86-2 |
| Molecular Formula | C40H78N4O8S |
| Purity | ≥95% |
| IUPAC Name | [(3R,6R)-6-[(3S,5R,7R,8R,9S,10S,13R,14S,17R)-3-[3-[4-(3-aminopropylamino)butylamino]propylamino]-7-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methylheptan-3-yl] hydrogen sulfate;2-hydroxypropanoic acid |
| InChI | InChI=1S/C37H72N4O5S.C3H6O3/c1-26(2)34(46-47(43,44)45)13-10-27(3)30-11-12-31-35-32(15-17-37(30,31)5)36(4)16-14-29(24-28(36)25-33(35)42)41-23-9-22-40-20-7-6-19-39-21-8-18-38;1-2(4)3(5)6/h26-35,39-42H,6-25,38H2,1-5H3,(H,43,44,45);2,4H,1H3,(H,5,6)/t27-,28-,29+,30-,31+,32+,33-,34-,35+,36+,37-;/m1./s1 |
| InChIKey | IVOWHCPDKHVRGQ-GMEVOBQHSA-N |
| SMILES | C[C@H](CC[C@H](C(C)C)OS(=O)(=O)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2[C@@H](C[C@@H]4[C@@]3(CC[C@@H](C4)NCCCNCCCCNCCCN)C)O)C.CC(C(=O)O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
