MSC-4381

• CAT Number: I045383
• CAS Number: 2445185-57-7
• Molecular Formula: C26H20ClN3O6S
• Molecular Weight: 537.97
• Purity: ≥95%
• Synonyms: 5-[2-[5-chloro-2-[(5-ethoxyquinolin-8-yl)sulfonylamino]phenyl]ethynyl]-4-methoxypyridine-2-carboxylic acid
• InChI: InChI=1S/C26H20ClN3O6S/c1-3-36-22-10-11-24(25-19(22)5-4-12-28-25)37(33,34)30-20-9-8-18(27)13-16(20)6-7-17-15-29-21(26(31)32)14-23(17)35-2/h4-5,8-15,30H,3H2,1-2H3,(H,31,32)
• InChIKey: FNBUZGRPJLEIMO-UHFFFAOYSA-N
• SMILES: CCOC1=C2C=CC=NC2=C(C=C1)S(=O)(=O)NC3=C(C=C(C=C3)Cl)C#CC4=CN=C(C=C4OC)C(=O)O

MSC-4381 (Cat No.: I045383) is a selective small-molecule agonist of the sphingosine-1-phosphate receptor 4 (S1P4), part of the S1P receptor family involved in immune regulation, inflammation, and lymphocyte trafficking. By specifically activating S1P4, MSC-4381 modulates immune cell signaling without broadly affecting other S1P receptors, potentially reducing side effects. It is primarily used in preclinical research to study the role of S1P4 in immune function, allergic responses, and inflammatory diseases, and to evaluate its therapeutic potential in autoimmune and respiratory conditions.

Reference

[1]. Timo Heinrich, et al. Discovery of 5-{2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic Acid, a Highly Selective in Vivo Useable Chemical Probe to Dissect MCT4 Biology. J Med Chem. 2021 Aug 26;64(16):11904-11933.
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