For research use only. Not for therapeutic Use.
MS31 trihydrochloride(CAT: I045993) is a potent, high-affinity, and selective inhibitor of the methyllysine reader protein spindlin 1 (SPIN1). It effectively blocks SPIN1 interaction with histone H3K4me3, showing inhibitory activity with IC₅₀ values of 77 nM (AlphaLISA) and 243 nM (FP). MS31 binds specifically to the Tudor domain II of SPIN1 (Kd = 91 nM), preventing recognition of trimethyllysine-containing peptides. With strong selectivity over other epigenetic readers and writers, it directly engages SPIN1 in cells while demonstrating minimal toxicity in non-tumorigenic cells. MS31 trihydrochloride is a valuable chemical probe for studying SPIN1-dependent transcriptional regulation and epigenetic signaling.
| CAS Number | 2748239-18-9 |
| Synonyms | [3-(aminomethyl)-5-[3-(1,3-dihydroisoindol-2-yl)propoxy]-4-methoxyphenyl]methanamine;trihydrochloride |
| Molecular Formula | C20H30Cl3N3O2 |
| Purity | ≥95% |
| IUPAC Name | [3-(aminomethyl)-5-[3-(1,3-dihydroisoindol-2-yl)propoxy]-4-methoxyphenyl]methanamine;trihydrochloride |
| InChI | InChI=1S/C20H27N3O2.3ClH/c1-24-20-18(12-22)9-15(11-21)10-19(20)25-8-4-7-23-13-16-5-2-3-6-17(16)14-23;;;/h2-3,5-6,9-10H,4,7-8,11-14,21-22H2,1H3;3*1H |
| InChIKey | ACLRXRSPMJPOKN-UHFFFAOYSA-N |
| SMILES | COC1=C(C=C(C=C1OCCCN2CC3=CC=CC=C3C2)CN)CN.Cl.Cl.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
