For research use only. Not for therapeutic Use.
MS170（Cat No.:I045155）is a potent and selective cereblon (CRBN)-recruiting PROTAC degrader that targets all three AKT isoforms. It depletes total cellular AKT (T-AKT) with a DC₅₀ of ~32 nM, binding AKT1, AKT2, and AKT3 with Kₑ values of 1.3 nM, 77 nM, and 6.5 nM, respectively. MS170 induces AKT degradation via the ubiquitin‑proteasome system without exhibiting a “hook effect”. It suppresses cancer cell proliferation in lines like BT474, PC3, and MDA‑MB‑468 (GI₅₀ ranging from ~0.7 to 7 µM) and demonstrates in vivo bioavailability in mice after intraperitoneal dosing (50 mg/kg, Cₘₐₓ ~1.4 µM at 2 h).
| CAS Number | 2376136-61-5 |
| Synonyms | 3-[[(2S)-2-(4-chlorophenyl)-3-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-oxopropyl]amino]-N-[8-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]octyl]propanamide |
| Molecular Formula | C45H56ClN9O7 |
| Purity | ≥95% |
| IUPAC Name | 3-[[(2S)-2-(4-chlorophenyl)-3-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-oxopropyl]amino]-N-[8-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]octyl]propanamide |
| InChI | InChI=1S/C45H56ClN9O7/c1-28-25-35(56)40-38(28)41(51-27-50-40)53-21-23-54(24-22-53)43(60)32(29-11-13-30(46)14-12-29)26-47-20-17-36(57)49-19-7-5-3-2-4-6-18-48-33-10-8-9-31-39(33)45(62)55(44(31)61)34-15-16-37(58)52-42(34)59/h8-14,27-28,32,34-35,47-48,56H,2-7,15-26H2,1H3,(H,49,57)(H,52,58,59)/t28-,32-,34?,35-/m1/s1 |
| InChIKey | QMLFGZYEQAMKRK-SCQVZNLVSA-N |
| SMILES | C[C@@H]1C[C@H](C2=C1C(=NC=N2)N3CCN(CC3)C(=O)[C@H](CNCCC(=O)NCCCCCCCCNC4=CC=CC5=C4C(=O)N(C5=O)C6CCC(=O)NC6=O)C7=CC=C(C=C7)Cl)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
