MS-PPOH

• CAT Number: R067365
• CAS Number: 206052-02-0
• Molecular Formula: C16H21NO4S
• Molecular Weight: 323.41
• Purity: ≥95%
• Synonyms: N-methylsulfonyl-6-(2-prop-2-ynoxyphenyl)hexanamide
• InChI: InChI=1S/C16H21NO4S/c1-3-13-21-15-11-8-7-10-14(15)9-5-4-6-12-16(18)17-22(2,19)20/h1,7-8,10-11H,4-6,9,12-13H2,2H3,(H,17,18)
• InChIKey: REUHFEYPDFRRGJ-UHFFFAOYSA-N
• SMILES: CS(=O)(=O)NC(=O)CCCCCC1=CC=CC=C1OCC#C

MS-PPOH (Cat No.: R067365) is a selective inhibitor of cytochrome P450 epoxygenases, particularly those involved in the metabolism of arachidonic acid to epoxyeicosatrienoic acids (EETs). By blocking EET formation, MS-PPOH is widely used to study vascular tone regulation, inflammation, and renal function. It has been applied in cardiovascular and renal research to dissect the physiological roles of epoxygenase-derived metabolites. MS-PPOH provides a valuable tool for exploring cytochrome P450–mediated pathways and their contribution to disease mechanisms and therapeutic strategies.

Reference

[1]. Kasem Nithipatikom, et al. Inhibition of carcinoma cell motility by epoxyeicosatrienoic acid (EET) antagonists. Cancer Sci. 2010 Dec;101(12):2629-36.
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[2]. Jun Yang, et al. Cytochrome P450 2C24: Expression, Tissue Distribution, High-Throughput Assay, and Pharmacological Inhibition. Acta Pharm Sin B. 2012 Apr;2(2):137-145.
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[3]. Jing Li, et al. Pharmacological manipulation of arachidonic acid-epoxygenase results in divergent effects on renal damage. Front Pharmacol. 2014 Aug 15;5:187.
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