For research use only. Not for therapeutic Use.
MRTX0902（Cat No.:I043968）is a potent and selective inhibitor of KRAS G12C, a common mutation found in various cancers, particularly non-small cell lung cancer (NSCLC). This small molecule works by covalently binding to the cysteine residue in the KRAS G12C mutant, locking it in an inactive state and preventing the activation of downstream signaling pathways involved in cell growth and survival. MRTX0902 has shown strong preclinical efficacy and is under investigation in clinical trials as a targeted therapy, offering a promising option for patients with KRAS G12C-driven malignancies.
| CAS Number | 2654743-22-1 |
| Synonyms | 2-methyl-3-[(1R)-1-[(4-methyl-7-morpholin-4-ylpyrido[3,4-d]pyridazin-1-yl)amino]ethyl]benzonitrile |
| Molecular Formula | C22H24N6O |
| Purity | ≥95% |
| IUPAC Name | 2-methyl-3-[(1R)-1-[(4-methyl-7-morpholin-4-ylpyrido[3,4-d]pyridazin-1-yl)amino]ethyl]benzonitrile |
| InChI | InChI=1S/C22H24N6O/c1-14-17(12-23)5-4-6-18(14)15(2)25-22-19-11-21(28-7-9-29-10-8-28)24-13-20(19)16(3)26-27-22/h4-6,11,13,15H,7-10H2,1-3H3,(H,25,27)/t15-/m1/s1 |
| InChIKey | ILPWEAHQRAWJIU-OAHLLOKOSA-N |
| SMILES | CC1=C(C=CC=C1[C@@H](C)NC2=NN=C(C3=CN=C(C=C32)N4CCOCC4)C)C#N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
