MRT67307 HCl

• CAT Number: I047362
• CAS Number: 1781882-89-0
• Molecular Formula: C26H36N6O2· xHCl
• Purity: ≥95%
• Storage: 3 years-20°Cpowder
• SMILES: C1CC(C1)C(=O)NCCCNC2=NC(=NC=C2C3CC3)NC4=CC=CC(=C4)CN5CCOCC5

MRT67307 is a potent and dual IKKϵ and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively. MRT67307 potently inhibits ULK1 and ULK2 and blocks autophagy.

Reference

[1] Clark K, et al. Biochem J. 2011, 434(1), 93-104.
[2] Clark K, et al. Proc Natl Acad Sci U S A. 2012, 109(42), 16986-16991.
[3] Petherick KJ, et al. J Biol Chem. 2015, 290(18), 11376-11383.