MRT-14

• CAT Number: I043972
• CAS Number: 1263131-83-4
• Molecular Formula: C24H24N4O5
• Molecular Weight: 448.47
• Purity: ≥95%
• Synonyms: N-[N’-(3-benzamidophenyl)carbamimidoyl]-3,4,5-trimethoxybenzamide
• IUPAC Name: N-[N'-(3-benzamidophenyl)carbamimidoyl]-3,4,5-trimethoxybenzamide
• InChI: InChI=1S/C24H24N4O5/c1-31-19-12-16(13-20(32-2)21(19)33-3)23(30)28-24(25)27-18-11-7-10-17(14-18)26-22(29)15-8-5-4-6-9-15/h4-14H,1-3H3,(H,26,29)(H3,25,27,28,30)
• InChIKey: CIWMWTKJZQOXBC-UHFFFAOYSA-N
• SMILES: COC1=CC(=CC(=C1OC)OC)C(=O)NC(=NC2=CC=CC(=C2)NC(=O)C3=CC=CC=C3)N

MRT-14（Cat No.:I043972）is a selective, small-molecule inhibitor of the MAPK-activated protein kinase 2 (MK2), a key regulator in cellular stress responses and inflammation. By inhibiting MK2, MRT-14 blocks the phosphorylation of downstream targets involved in cytokine production, cell survival, and stress responses, which are central to inflammatory diseases. It has shown promise in preclinical models for reducing inflammation and tissue damage in conditions like rheumatoid arthritis, inflammatory bowel disease, and certain cancers. MRT-14’s targeted inhibition of MK2 offers a novel approach to treating inflammation-driven diseases with minimal off-target effects.