For research use only. Not for therapeutic Use.
MRS 1523(CAT:I008186) is a potent and selective adenosine A₃ receptor (A₃AR) antagonist, with Kᵢ values of 18.9 nM (human) and 113 nM (rat), demonstrating strong selectivity over A₁ and A₂A receptors. In neuronal studies, MRS 1523 exerts antihyperalgesic effects by blocking N-type Ca²⁺ channels and suppressing action potentials in rat dorsal root ganglion (DRG) neurons. It also antagonizes cordycepin-induced tumor cell growth and inhibits NECA-induced endothelial progenitor cell migration in a dose-dependent manner (Kᵢ = 147 nM). By modulating A₃AR signaling, MRS 1523 is a valuable pharmacological tool for investigating pain mechanisms, cancer biology, and vascular function.
| CAS Number | 212329-37-8 |
| Synonyms | propyl 6-ethyl-5-ethylsulfanylcarbonyl-2-phenyl-4-propylpyridine-3-carboxylate |
| Molecular Formula | C23H29NO3S |
| Purity | ≥95% |
| IUPAC Name | propyl 6-ethyl-5-ethylsulfanylcarbonyl-2-phenyl-4-propylpyridine-3-carboxylate |
| InChI | InChI=1S/C23H29NO3S/c1-5-12-17-19(23(26)28-8-4)18(7-3)24-21(16-13-10-9-11-14-16)20(17)22(25)27-15-6-2/h9-11,13-14H,5-8,12,15H2,1-4H3 |
| InChIKey | UUSHFEVEROROSP-UHFFFAOYSA-N |
| SMILES | CCCC1=C(C(=NC(=C1C(=O)SCC)CC)C2=CC=CC=C2)C(=O)OCCC |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
