MRK-016 - CAS 783331-24-8

MRK-016 (Cat.No:I008016) is a selective α5 subunit-containing GABAA negative allosteric modulator that has nootropic properties. It has been found to produce rapid, ketamine-like antidepressant effects in animal models of depression.

Catalog Number: I008016

CAS Number: 783331-24-8

PubChem Substance ID:355182285

Molecular Formula: C17H20N8O2

Molecular Weight:368.401

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

SynonymsMRK-016; MRK 016; MRK016.;3-tert-Butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)pyrazolo(1,5-d)(1,2,4)triazine

Property

Molecular Formula: C17H20N8O2
Molecular Weight368.401
Target:GABA Receptor
SolubilitySoluble in DMSO, not in water
Purity≥95%
StorageStore at +4C

Computed Descriptor

IUPAC Name3-[3-tert-butyl-2-[(2-methyl-1,2,4-triazol-3-yl)methoxy]pyrazolo[1,5-d][1,2,4]triazin-7-yl]-5-methyl-1,2-oxazole
InChIInChI=1S/C17H20N8O2/c1-10-6-11(23-27-10)15-21-19-7-12-14(17(2,3)4)16(22-25(12)15)26-8-13-18-9-20-24(13)5/h6-7,9H,8H2,1-5H3
InChIKeyQYSYOGCIDRANAR-UHFFFAOYSA-N
SMILESCC1=CC(=NO1)C2=NN=CC3=C(C(=NN32)OCC4=NC=NN4C)C(C)(C)C