For research use only. Not for therapeutic Use.
MrgprX2 antagonist-4（Cat No.:I045162）is a potent and selective inhibitor of the Mas-related G protein-coupled receptor X2 (MrgprX2), a receptor primarily expressed on mast cells and implicated in pseudo-allergic and non-IgE-mediated hypersensitivity reactions. By blocking MrgprX2 activation, this antagonist prevents mast cell degranulation and the subsequent release of histamine and inflammatory mediators. It is a valuable research tool for elucidating MrgprX2’s role in allergic responses, chronic inflammation, and drug-induced hypersensitivity. MrgprX2 antagonist-4 holds potential for developing novel therapies targeting mast cell–mediated disorders without compromising protective immune functions.
| CAS Number | 2641398-04-9 |
| Synonyms | 3-ethyl-7-methyl-2-propan-2-yl-1H-pyrimido[1,2-a]benzimidazol-4-one |
| Molecular Formula | C16H19N3O |
| Purity | ≥95% |
| IUPAC Name | 3-ethyl-7-methyl-2-propan-2-yl-1H-pyrimido[1,2-a]benzimidazol-4-one |
| InChI | InChI=1S/C16H19N3O/c1-5-11-14(9(2)3)18-16-17-12-7-6-10(4)8-13(12)19(16)15(11)20/h6-9H,5H2,1-4H3,(H,17,18) |
| InChIKey | GEBQJASGYKVDHG-UHFFFAOYSA-N |
| SMILES | CCC1=C(NC2=NC3=C(N2C1=O)C=C(C=C3)C)C(C)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
