For research use only. Not for therapeutic Use.
MrgprX2 antagonist-3（Cat No.:I045163）is a potent, selective inhibitor of the Mas-related G protein-coupled receptor X2 (MrgprX2), a key mediator of non-IgE-dependent mast cell activation. By blocking MrgprX2 signaling, it suppresses mast cell degranulation and the release of histamine and pro-inflammatory mediators, thereby reducing pseudo-allergic and drug-induced hypersensitivity reactions. This antagonist serves as an important tool for studying mast cell–driven pathways in allergic, inflammatory, and dermatological disorders. MrgprX2 antagonist-3 shows promise for developing targeted therapies that mitigate pathological immune responses while preserving essential host defense mechanisms.
| CAS Number | 2642174-19-2 |
| Synonyms | 1-ethyl-3-[5-[(3-fluorophenyl)methyl]-1,3-thiazol-2-yl]-1-[(2S)-2-hydroxypropyl]urea |
| Molecular Formula | C16H20FN3O2S |
| Purity | ≥95% |
| IUPAC Name | 1-ethyl-3-[5-[(3-fluorophenyl)methyl]-1,3-thiazol-2-yl]-1-[(2S)-2-hydroxypropyl]urea |
| InChI | InChI=1S/C16H20FN3O2S/c1-3-20(10-11(2)21)16(22)19-15-18-9-14(23-15)8-12-5-4-6-13(17)7-12/h4-7,9,11,21H,3,8,10H2,1-2H3,(H,18,19,22)/t11-/m0/s1 |
| InChIKey | SQINLEDSAKOIRP-NSHDSACASA-N |
| SMILES | CCN(C[C@H](C)O)C(=O)NC1=NC=C(S1)CC2=CC(=CC=C2)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
