MrgprX2 antagonist-1

• CAT Number: I045165
• CAS Number: 2642162-06-7
• Molecular Formula: C15H15F5N4O2S
• Molecular Weight: 410.36
• Purity: ≥95%
• Synonyms: 3-[5-[(3,5-difluorophenyl)methyl]-1,3,4-thiadiazol-2-yl]-1-ethyl-1-[(2R)-3,3,3-trifluoro-2-hydroxypropyl]urea
• InChI: InChI=1S/C15H15F5N4O2S/c1-2-24(7-11(25)15(18,19)20)14(26)21-13-23-22-12(27-13)5-8-3-9(16)6-10(17)4-8/h3-4,6,11,25H,2,5,7H2,1H3,(H,21,23,26)/t11-/m1/s1
• InChIKey: QJCRGWUNWPWJCQ-LLVKDONJSA-N
• SMILES: CCN(C[C@H](C(F)(F)F)O)C(=O)NC1=NN=C(S1)CC2=CC(=CC(=C2)F)F

MrgprX2 antagonist-1（Cat No.:I045165）is a potent, selective inhibitor of the Mas-related G protein-coupled receptor X2 (MrgprX2), a mast cell–expressed receptor implicated in non-IgE-mediated hypersensitivity and pseudo-allergic reactions. By blocking MrgprX2 signaling, it prevents mast cell degranulation and the subsequent release of histamine and pro-inflammatory mediators, thereby mitigating drug-induced and chronic inflammatory responses. This antagonist is a valuable research tool for investigating mast cell–driven immunopathology and allergic mechanisms. MrgprX2 antagonist-1 holds therapeutic potential for treating mast cell–mediated disorders while preserving normal immune defense functions.