For research use only. Not for therapeutic Use.
Mps1-IN-3 hydrochloride（Cat No.:I043591）is a potent and selective inhibitor of monopolar spindle 1 (Mps1) kinase, a key regulator of the spindle assembly checkpoint during mitosis. By blocking Mps1 activity, this compound disrupts proper chromosome alignment and segregation, leading to mitotic errors and cell death—particularly in rapidly dividing cancer cells. Mps1-IN-3 hydrochloride is being investigated for its potential in cancer therapy, especially in tumors with heightened mitotic activity. It also serves as a valuable research tool for studying mitotic checkpoint control and exploring therapeutic strategies that exploit mitotic vulnerabilities in cancer cells.
| CAS Number | 2989453-29-2 |
| Synonyms | 1-[3-methoxy-4-[[6-(2-propan-2-ylsulfonylanilino)-7H-purin-2-yl]amino]phenyl]piperidin-4-ol;hydrochloride |
| Molecular Formula | C26H32ClN7O4S |
| Purity | ≥95% |
| IUPAC Name | 1-[3-methoxy-4-[[6-(2-propan-2-ylsulfonylanilino)-7H-purin-2-yl]amino]phenyl]piperidin-4-ol;hydrochloride |
| InChI | InChI=1S/C26H31N7O4S.ClH/c1-16(2)38(35,36)22-7-5-4-6-20(22)29-25-23-24(28-15-27-23)31-26(32-25)30-19-9-8-17(14-21(19)37-3)33-12-10-18(34)11-13-33;/h4-9,14-16,18,34H,10-13H2,1-3H3,(H3,27,28,29,30,31,32);1H |
| InChIKey | BDKTZCBXQCCHRK-UHFFFAOYSA-N |
| SMILES | CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC3=C2NC=N3)NC4=C(C=C(C=C4)N5CCC(CC5)O)OC.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
