Monomethyl auristatin E intermediate-9

• CAT Number: I040446
• CAS Number: 120205-58-5
• Molecular Formula: C22H35NO5
• Molecular Weight: 393.52
• Purity: ≥95%
• Synonyms: tert-butyl (3R,4S,5S)-3-methoxy-5-methyl-4-[methyl(phenylmethoxycarbonyl)amino]heptanoate
• InChI: InChI=1S/C22H35NO5/c1-8-16(2)20(18(26-7)14-19(24)28-22(3,4)5)23(6)21(25)27-15-17-12-10-9-11-13-17/h9-13,16,18,20H,8,14-15H2,1-7H3/t16-,18+,20-/m0/s1
• InChIKey: PCUHBNWYHLQSBO-HQRMLTQVSA-N
• SMILES: CCC(C)C(C(CC(=O)OC(C)(C)C)OC)N(C)C(=O)OCC1=CC=CC=C1

Monomethyl auristatin E Intermediate-9(CAT: I040446) is a vital synthetic reagent in the multi-step construction of Monomethyl Auristatin E (MMAE, HY-15162), a highly potent tubulin polymerization inhibitor used as a cytotoxic payload in antibody-drug conjugates (ADCs). MMAE disrupts microtubule dynamics, inducing mitotic arrest and apoptosis in rapidly proliferating cancer cells. Intermediate-9 contributes to the formation of MMAE’s complex peptide-like structure, enabling precision and efficiency in large-scale synthesis. This intermediate supports the development of advanced targeted cancer therapies such as ADCs by ensuring consistent and high-purity production of MMAE. It is essential in both research and manufacturing workflows focused on cytotoxic payloads.