Monomethyl auristatin E intermediate-7

• CAT Number: I040447
• CAS Number: 135383-55-0
• Molecular Formula: C20H31NO5
• Molecular Weight: 365.46
• Purity: ≥95%
• Synonyms: tert-butyl (3R,4S,5S)-3-hydroxy-5-methyl-4-(phenylmethoxycarbonylamino)heptanoate
• InChI: InChI=1S/C20H31NO5/c1-6-14(2)18(16(22)12-17(23)26-20(3,4)5)21-19(24)25-13-15-10-8-7-9-11-15/h7-11,14,16,18,22H,6,12-13H2,1-5H3,(H,21,24)/t14-,16+,18-/m0/s1
• InChIKey: AZTSBAWJROLRIQ-LESCRADOSA-N
• SMILES: CCC(C)C(C(CC(=O)OC(C)(C)C)O)NC(=O)OCC1=CC=CC=C1

Monomethyl auristatin E Intermediate-7(CAT: I040447) is a critical building block in the synthesis of Monomethyl Auristatin E (MMAE), a highly potent antimitotic agent commonly used as the cytotoxic payload in antibody-drug conjugates (ADCs). This intermediate enables the stepwise construction of the complex MMAE structure, contributing to its activity as a tubulin polymerization inhibitor. Intermediate-7 is typically employed in the assembly of the peptide-like backbone and functional moieties necessary for drug conjugation. Its precise configuration and high reactivity make it essential for producing MMAE with the purity and bioactivity required for targeted cancer therapies, particularly in ADC manufacturing workflows.

Reference

[1]. Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87.
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