Monomethyl auristatin E intermediate-3

• CAT Number: I040261
• Molecular Formula: C14H19NO4
• Molecular Weight: 265.30
• Purity: ≥95%
• Synonyms: 3-methyl-2-(phenylmethoxycarbonylamino)pentanoic acid
• InChI: InChI=1S/C14H19NO4/c1-3-10(2)12(13(16)17)15-14(18)19-9-11-7-5-4-6-8-11/h4-8,10,12H,3,9H2,1-2H3,(H,15,18)(H,16,17)
• InChIKey: JSHXJPFZKBRLFU-UHFFFAOYSA-N
• SMILES: CCC(C)C(C(=O)O)NC(=O)OCC1=CC=CC=C1

Monomethyl auristatin E intermediate-3(CAT: I040261) is a critical synthetic building block in the preparation of Monomethyl auristatin E (MMAE, HY-15162), a powerful microtubule polymerization inhibitor with well-established anticancer activity. As a precursor in MMAE synthesis, intermediate-3 plays an essential role in assembling the complex peptide structure of this cytotoxic agent. MMAE is extensively utilized as the toxic payload in antibody-drug conjugates (ADCs), enabling targeted delivery of chemotherapy to tumor cells. Monomethyl auristatin E intermediate-3 is ideal for researchers engaged in ADC development, cytotoxic payload optimization, and synthetic studies in oncology drug design.