Monomethyl auristatin E intermediate-2

• CAT Number: I040258
• Molecular Formula: C15H27NO6
• Molecular Weight: 317.38
• Purity: ≥95%
• Synonyms: (2R,3R)-3-(methoxymethoxy)-2-methyl-3-[(2S)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidin-2-yl]propanoic acid
• InChI: InChI=1S/C15H27NO6/c1-10(13(17)18)12(21-9-20-5)11-7-6-8-16(11)14(19)22-15(2,3)4/h10-12H,6-9H2,1-5H3,(H,17,18)/t10-,11+,12-/m1/s1
• InChIKey: XXJRADINQBEQRW-GRYCIOLGSA-N
• SMILES: CC(C(C1CCCN1C(=O)OC(C)(C)C)OCOC)C(=O)O

Monomethyl auristatin E intermediate-2(CAT: I040258) is a key synthetic intermediate used in the production of Monomethyl auristatin E (MMAE, HY-15162), a highly potent microtubule inhibitor with broad-spectrum anticancer activity. MMAE functions by disrupting tubulin polymerization, inducing cell cycle arrest and apoptosis. It is widely employed as the cytotoxic payload in antibody-drug conjugates (ADCs) for targeted cancer therapy. Intermediate-2 is essential for the stepwise assembly of MMAE’s complex structure, and is ideal for researchers engaged in ADC payload synthesis, cytotoxic drug design, and structure–activity relationship (SAR) studies in oncology.