Monomethyl auristatin E intermediate-15

• CAT Number: I040442
• CAS Number: 173653-47-9
• Molecular Formula: C20H29NO5
• Molecular Weight: 363.45
• Purity: ≥95%
• Synonyms: tert-butyl (2S)-2-[(1R,2S)-1-hydroxy-2-methyl-3-oxo-3-phenylmethoxypropyl]pyrrolidine-1-carboxylate
• InChI: InChI=1S/C20H29NO5/c1-14(18(23)25-13-15-9-6-5-7-10-15)17(22)16-11-8-12-21(16)19(24)26-20(2,3)4/h5-7,9-10,14,16-17,22H,8,11-13H2,1-4H3/t14-,16-,17+/m0/s1
• InChIKey: IJTMTCBOXNAACY-BHYGNILZSA-N
• SMILES: CC(C(C1CCCN1C(=O)OC(C)(C)C)O)C(=O)OCC2=CC=CC=C2

Monomethyl auristatin E Intermediate-15(CAT: I040442) is a critical synthetic intermediate in the preparation of Monomethyl Auristatin E (MMAE, HY-15162), a potent microtubule inhibitor used extensively as a cytotoxic payload in antibody-drug conjugates (ADCs). MMAE exerts its anticancer effects by disrupting tubulin polymerization, leading to mitotic arrest and apoptosis in proliferating tumor cells. Intermediate-15 enables precise and efficient stepwise assembly of the complex MMAE structure, ensuring high purity and functionality for targeted therapeutic applications. This intermediate is essential in ADC payload synthesis workflows, supporting the development and manufacture of next-generation targeted cancer therapies with enhanced selectivity and cytotoxic potency.