Monomethyl auristatin E intermediate-14

• CAT Number: I040444
• CAS Number: 1932791-56-4
• Molecular Formula: C13H19NO2
• Molecular Weight: 221.30
• Purity: ≥95%
• Synonyms: (2R,3S)-2-(benzylamino)-3-methylpentanoic acid
• InChI: InChI=1S/C13H19NO2/c1-3-10(2)12(13(15)16)14-9-11-7-5-4-6-8-11/h4-8,10,12,14H,3,9H2,1-2H3,(H,15,16)/t10-,12+/m0/s1
• InChIKey: GPAVORZIWQTJJQ-CMPLNLGQSA-N
• SMILES: CCC(C)C(C(=O)O)NCC1=CC=CC=C1

Monomethyl auristatin E Intermediate-14(CAT: I040444) is a key synthetic intermediate used in the stepwise construction of Monomethyl Auristatin E (MMAE, HY-15162), a potent tubulin polymerization inhibitor with well-established anticancer properties. As a foundational reagent in MMAE synthesis, Intermediate-14 plays a crucial role in assembling the highly active peptide-based structure of the final cytotoxic payload. MMAE is commonly employed as the warhead in antibody-drug conjugates (ADCs), enabling targeted delivery of cytotoxic agents to cancer cells. Intermediate-14 supports efficient manufacturing processes and facilitates the development of next-generation ADCs for cancer therapy, ensuring precision, potency, and scalability in payload synthesis.