Monomethyl auristatin E intermediate-11

• CAT Number: I040445
• CAS Number: 870640-62-3
• Molecular Formula: C14H23NO
• Molecular Weight: 221.34
• Purity: ≥95%
• Synonyms: (2S,3S)-2-[benzyl(methyl)amino]-3-methylpentan-1-ol
• InChI: InChI=1S/C14H23NO/c1-4-12(2)14(11-16)15(3)10-13-8-6-5-7-9-13/h5-9,12,14,16H,4,10-11H2,1-3H3/t12-,14+/m0/s1
• InChIKey: JPXSDNBZAYWWCL-GXTWGEPZSA-N
• SMILES: CCC(C)C(CO)N(C)CC1=CC=CC=C1

Monomethyl auristatin E Intermediate-11(CAT: I040445) is a crucial synthetic intermediate in the preparation of Monomethyl Auristatin E (MMAE, HY-15162), a potent cytotoxic agent that functions as a microtubule/tubulin inhibitor. MMAE is widely utilized as the payload in antibody-drug conjugates (ADCs), delivering targeted cytotoxicity to cancer cells through inhibition of cell division. Intermediate-11 plays a key role in constructing the complex peptide-like structure of MMAE, supporting efficient and high-fidelity synthesis. It is essential for ADC development workflows, enabling the production of highly purified and bioactive MMAE for next-generation targeted cancer therapies. Suitable for use in pharmaceutical research and cytotoxin manufacturing.