MOMIPP

• CAT Number: I032563
• CAS Number: 1363421-46-8
• Molecular Formula: C18H16N2O2
• Molecular Weight: 292.33
• Purity: ≥95%
• Synonyms: (E)-3-(5-methoxy-2-methyl-1H-indol-3-yl)-1-pyridin-4-ylprop-2-en-1-one
• InChI: InChI=1S/C18H16N2O2/c1-12-15(4-6-18(21)13-7-9-19-10-8-13)16-11-14(22-2)3-5-17(16)20-12/h3-11,20H,1-2H3/b6-4+
• InChIKey: UPJCYXIOWHZRLU-GQCTYLIASA-N
• SMILES: CC1=C(C2=C(N1)C=CC(=C2)OC)C=CC(=O)C3=CC=NC=C3

MOMIPP (Cat No.: I032563) is a synthetic small-molecule inducer of methuosis, a non-apoptotic form of cell death characterized by massive vacuolization of the cytoplasm. Unlike traditional apoptosis inducers, MOMIPP disrupts endocytic trafficking, leading to accumulation of dysfunctional vacuoles and eventual cell death. It has been widely used in cancer research to explore alternative cell death pathways and overcome resistance to apoptosis-based therapies. MOMIPP provides a valuable experimental tool for studying endocytosis, non-apoptotic cell death mechanisms, and potential anticancer strategies.

Reference

[1]. Margaux Colin, et al. Dysregulation of Macropinocytosis Processes in Glioblastomas May Be Exploited to Increase Intracellular Anti-Cancer Drug Levels: The Example of Temozolomide. Cancers (Basel). 2019 Mar 22;11(3):411.
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[2]. Zehui Li, et al. The JNK signaling pathway plays a key role in methuosis (non-apoptotic cell death) induced by MOMIPP in glioblastoma. BMC Cancer. 2019 Jan 16;19(1):77.
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