For research use only. Not for therapeutic Use.
MNI137（Cat No.:I008124）is a potent and selective negative allosteric modulator of group II metabotropic glutamate receptors (mGluRs), particularly mGlu2. It inhibits glutamate-induced calcium mobilization with IC₅₀ values of 8.3 nM in humans and 12.6 nM in rats. Notably, MNI137 exhibits no significant activity at other mGluR subtypes such as mGlu1, mGlu4, mGlu5, or mGlu8, underscoring its high selectivity . This compound is valuable in neuroscience research for elucidating the roles of mGlu2 in synaptic transmission and neurological disorders. Its specificity makes it a useful tool for probing glutamatergic signaling pathways and exploring therapeutic avenues for conditions like anxiety, schizophrenia, and depression.
| CAS Number | 946619-21-2 |
| Synonyms | 4-(8-bromo-2-oxo-1,3-dihydro-1,5-benzodiazepin-4-yl)pyridine-2-carbonitrile |
| Molecular Formula | C15H9BrN4O |
| Purity | ≥95% |
| IUPAC Name | 4-(8-bromo-2-oxo-1,3-dihydro-1,5-benzodiazepin-4-yl)pyridine-2-carbonitrile |
| InChI | InChI=1S/C15H9BrN4O/c16-10-1-2-12-14(6-10)20-15(21)7-13(19-12)9-3-4-18-11(5-9)8-17/h1-6H,7H2,(H,20,21) |
| InChIKey | KMKZCMKOSAKVGY-UHFFFAOYSA-N |
| SMILES | C1C(=NC2=C(C=C(C=C2)Br)NC1=O)C3=CC(=NC=C3)C#N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
