MMP-2/MMP-9-IN-1

• CAT Number: I011667
• CAS Number: 193807-58-8
• Molecular Formula: C21H19NO4S
• Molecular Weight: 381.44
• Purity: ≥95%
• Synonyms: (2R)-3-phenyl-2-[(4-phenylphenyl)sulfonylamino]propanoic acid
• IUPAC Name: 3-phenyl-2-[(4-phenylphenyl)sulfonylamino]propanoic acid
• InChI: InChI=1S/C21H19NO4S/c23-21(24)20(15-16-7-3-1-4-8-16)22-27(25,26)19-13-11-18(12-14-19)17-9-5-2-6-10-17/h1-14,20,22H,15H2,(H,23,24)
• InChIKey: JBYHBQIDTNHWJF-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)CC(C(=O)O)NS(=O)(=O)C2=CC=C(C=C2)C3=CC=CC=C3

​MMP-2/MMP-9-IN-1（Cat No.:I011667）is a potent, selective, and orally bioavailable inhibitor targeting matrix metalloproteinases MMP-2 and MMP-9, key enzymes in extracellular matrix degradation linked to tumor invasion and metastasis. It exhibits IC₅₀ values of 0.31 μM for MMP-2 and 0.24 μM for MMP-9. In preclinical models, MMP-2/MMP-9-IN-1 significantly suppresses tumor growth and metastasis, notably reducing lung colonization by Lewis lung carcinoma cells and extending survival in mice with Ma44 peritoneal tumors. Its high selectivity and oral activity make it a valuable tool for cancer research and potential therapeutic development.