For research use only. Not for therapeutic Use.
MMH2(CAT: I040274) is a novel BRD4 molecular glue degrader that selectively targets the second bromodomain of BRD4 (BRD4^BD2). Unlike traditional PROTACs, MMH2 functions by stabilizing the interaction between BRD4 and the E3 ligase complex CUL4-DCAF16, promoting ubiquitination and proteasomal degradation of BRD4. This mechanism offers a unique approach to epigenetic regulation by eliminating BRD4, a key transcriptional coactivator implicated in cancer and inflammation. MMH2 is a valuable chemical probe for studying targeted protein degradation via molecular glue strategies and BRD4-mediated transcriptional control.
| Synonyms | tert-butyl 2-[(9S)-7-[4-(ethenylsulfonylamino)phenyl]-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetate |
| Molecular Formula | C25H29N5O4S2 |
| Purity | ≥95% |
| IUPAC Name | tert-butyl 2-[(9S)-7-[4-(ethenylsulfonylamino)phenyl]-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetate |
| InChI | InChI=1S/C25H29N5O4S2/c1-8-36(32,33)29-18-11-9-17(10-12-18)22-21-14(2)15(3)35-24(21)30-16(4)27-28-23(30)19(26-22)13-20(31)34-25(5,6)7/h8-12,19,29H,1,13H2,2-7H3/t19-/m0/s1 |
| InChIKey | FZRRESXAODIMQN-IBGZPJMESA-N |
| SMILES | CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)NS(=O)(=O)C=C)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
