MMAF-OMe

• CAT Number: I005184
• CAS Number: 863971-12-4
• Molecular Formula: C40H67N5O8
• Molecular Weight: 745.99
• Purity: ≥95%
• Target: tubulin
• Solubility: DMSO
• Storage: -20°C

MMAF-OMe inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4-) cell lines, respectively.IC50:Target:tubulinIn vitro:In vivo: 2.5F-Fc and 2.5F-Fc-MMAF have similar IC50 values (6.9 ± 1.1 vs. 8.3 ± 1.3 nmol/L, respectively), indicating that MMAF conjugation has negligible impact on integrin-binding affinity[1].

Reference

[1]. Currier NV, et al. Targeted Drug Delivery with an Integrin-Binding Knottin-Fc-MMAF Conjugate Produced by Cell-Free Protein Synthesis. Mol Cancer Ther. 2016 Jun;15(6):1291-300.

[2]. Stephan JP, et al. Anti-CD22-MCC-DM1 and MC-MMAF conjugates: impact of assay format on pharmacokinetic parameters determination. Bioconjug Chem. 2008 Aug;19(8):1673-83.

[3]. Wils J, et al. MMAF for advanced gastric cancer. Eur J Cancer. 1992;28A(6-7):1299.

[4]. Anderson H, et al. MMAF for advanced gastric cancer. Eur J Cancer. 1991;27(10):1234-8.