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MMAF-OMe

MMAF-OMe

  • CAT Number: I005184
  • CAS Number: 863971-12-4
  • Molecular Formula: C40H67N5O8
  • Molecular Weight: 745.99
  • Purity: ≥95%
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<p style=/line-height:25px/>MMAF-OMe inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4-) cell lines, respectively.<br>IC50:<br>Target:tubulin<br>In vitro:<br>In vivo: 2.5F-Fc and 2.5F-Fc-MMAF have similar IC50 values (6.9 ± 1.1 vs. 8.3 ± 1.3 nmol/L, respectively), indicating that MMAF conjugation has negligible impact on integrin-binding affinity[1].</p>

Catalog Number I005184
CAS Number 863971-12-4
Molecular Formula

C40H67N5O8

Purity 95%
Target tubulin
Solubility DMSO
Storage -20°C
Reference

<p style=/line-height:25px/>
<br>[1]. Currier NV, et al. Targeted Drug Delivery with an Integrin-Binding Knottin-Fc-MMAF Conjugate Produced by Cell-Free Protein Synthesis. Mol Cancer Ther. 2016 Jun;15(6):1291-300.

<br>[2]. Stephan JP, et al. Anti-CD22-MCC-DM1 and MC-MMAF conjugates: impact of assay format on pharmacokinetic parameters determination. Bioconjug Chem. 2008 Aug;19(8):1673-83.

<br>[3]. Wils J, et al. MMAF for advanced gastric cancer. Eur J Cancer. 1992;28A(6-7):1299.

<br>[4]. Anderson H, et al. MMAF for advanced gastric cancer. Eur J Cancer. 1991;27(10):1234-8.

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