For research use only. Not for therapeutic Use.
MM11253（Cat No.:I008117）is a potent and selective inhibitor of the Notch1 transcriptional activation complex, designed to disrupt aberrant Notch signaling implicated in various cancers, particularly T-cell acute lymphoblastic leukemia (T-ALL). By preventing the assembly of the Notch1 transcriptional complex, MM11253 effectively blocks downstream gene expression without interfering with γ-secretase activity, offering a targeted approach with reduced off-target effects. It is used in cancer research to explore the role of Notch1 in tumor progression and resistance mechanisms. MM11253 supports the development of novel therapies targeting Notch-driven malignancies with improved selectivity and efficacy.
| CAS Number | 345952-44-5 |
| Synonyms | 6-[2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)-1,3-dithiolan-2-yl]naphthalene-2-carboxylic acid |
| Molecular Formula | C28H30O2S2 |
| Purity | ≥95% |
| IUPAC Name | 6-[2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)-1,3-dithiolan-2-yl]naphthalene-2-carboxylic acid |
| InChI | InChI=1S/C28H30O2S2/c1-26(2)11-12-27(3,4)24-17-22(9-10-23(24)26)28(31-13-14-32-28)21-8-7-18-15-20(25(29)30)6-5-19(18)16-21/h5-10,15-17H,11-14H2,1-4H3,(H,29,30) |
| InChIKey | DPVGXUNWCVEIGT-UHFFFAOYSA-N |
| SMILES | CC1(CCC(C2=C1C=CC(=C2)C3(SCCS3)C4=CC5=C(C=C4)C=C(C=C5)C(=O)O)(C)C)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
