For research use only. Not for therapeutic Use.
MLT-943（Cat No.:I044538）is a potent and selective inhibitor of salt-inducible kinase 2 (SIK2), an enzyme implicated in metabolic regulation, inflammation, and cancer progression. By blocking SIK2 activity, MLT-943 modulates key signaling pathways, including CREB-mediated transcription, offering therapeutic potential in inflammatory and metabolic disorders. The compound exhibits favorable pharmacokinetics and robust in vivo activity in preclinical models. Its specificity allows for targeted investigation of SIK2’s role in disease without broadly affecting related kinases. MLT-943 serves as both a research probe and a potential lead compound for developing novel SIK2-targeted therapies.
| CAS Number | 1832576-04-1 |
| Synonyms | 1-[2-chloro-7-[(1S)-1-methoxyethyl]pyrazolo[1,5-a]pyrimidin-6-yl]-3-[2-(trifluoromethyl)pyridin-4-yl]urea |
| Molecular Formula | C16H14ClF3N6O2 |
| Purity | ≥95% |
| IUPAC Name | 1-[2-chloro-7-[(1S)-1-methoxyethyl]pyrazolo[1,5-a]pyrimidin-6-yl]-3-[2-(trifluoromethyl)pyridin-4-yl]urea |
| InChI | InChI=1S/C16H14ClF3N6O2/c1-8(28-2)14-10(7-22-13-6-12(17)25-26(13)14)24-15(27)23-9-3-4-21-11(5-9)16(18,19)20/h3-8H,1-2H3,(H2,21,23,24,27)/t8-/m0/s1 |
| InChIKey | ZMPUACZRXUZAJD-QMMMGPOBSA-N |
| SMILES | C[C@@H](C1=C(C=NC2=CC(=NN21)Cl)NC(=O)NC3=CC(=NC=C3)C(F)(F)F)OC |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
