MLS1082

• CAT Number: I032443
• CAS Number: 883958-36-9
• Molecular Formula: C24H23N3O2
• Molecular Weight: 385.46
• Purity: ≥95%
• Synonyms: 2-cyclohexyl-10-methyl-3-phenylpyrimido[4,5-b]quinoline-4,5-dione
• InChI: InChI=1S/C24H23N3O2/c1-26-19-15-9-8-14-18(19)21(28)20-23(26)25-22(16-10-4-2-5-11-16)27(24(20)29)17-12-6-3-7-13-17/h3,6-9,12-16H,2,4-5,10-11H2,1H3
• InChIKey: HZGMAMIIHBRAAR-UHFFFAOYSA-N
• SMILES: CN1C2=CC=CC=C2C(=O)C3=C1N=C(N(C3=O)C4=CC=CC=C4)C5CCCCC5

MLS1082 (Cat No.: I032443) is a small-molecule inhibitor identified for its ability to modulate the Hedgehog (Hh) signaling pathway, which plays a critical role in embryonic development, stem cell maintenance, and cancer progression. By targeting key components of the pathway, MLS1082 suppresses Hh-mediated transcriptional activity, potentially reducing tumor growth in Hh-dependent cancers. It is primarily used in developmental biology and oncology research to study pathway regulation, ligand–receptor interactions, and downstream effects, as well as to explore therapeutic strategies for Hedgehog-driven malignancies and related disorders.

Reference

[1]. Kathryn D Luderman, et al. Development of pyrimidone D1 dopamine receptor positive allosteric modulators. Bioorg Med Chem Lett. 2021 Jan 1;31:127696.
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[2]. Kathryn D Luderman, et al. Identification of Positive Allosteric Modulators of the D 1 Dopamine Receptor That Act at Diverse Binding Sites. Mol Pharmacol. 2018 Oct;94(4):1197-1209.
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