MLKL-IN-2

• CAT Number: I045223
• CAS Number: 899759-16-1
• Molecular Formula: C26H25N5O
• Molecular Weight: 423.51
• Purity: ≥95%
• Synonyms: N-[3-[6-(4-methylpiperazin-1-yl)pyridazin-3-yl]phenyl]naphthalene-2-carboxamide
• InChI: InChI=1S/C26H25N5O/c1-30-13-15-31(16-14-30)25-12-11-24(28-29-25)21-7-4-8-23(18-21)27-26(32)22-10-9-19-5-2-3-6-20(19)17-22/h2-12,17-18H,13-16H2,1H3,(H,27,32)
• InChIKey: CVHOXUUPSXOTPM-UHFFFAOYSA-N
• SMILES: CN1CCN(CC1)C2=NN=C(C=C2)C3=CC(=CC=C3)NC(=O)C4=CC5=CC=CC=C5C=C4

MLKL-IN-2（Cat No.:I045223）is a potent, selective inhibitor of mixed lineage kinase domain-like protein (MLKL), a terminal effector of necroptosis, a regulated form of inflammatory cell death. By blocking MLKL activation and membrane translocation, MLKL-IN-2 prevents plasma membrane disruption and release of pro-inflammatory cellular contents. It is a valuable research tool for studying necroptosis signaling, inflammation, and cell death regulation. MLKL-IN-2 holds therapeutic potential for treating diseases where necroptosis contributes to pathology, including neurodegeneration, ischemia-reperfusion injury, and inflammatory disorders, while preserving other cell death pathways such as apoptosis for normal tissue homeostasis.