For research use only. Not for therapeutic Use.
ML380（Cat No.:I008105）is a potent and selective inhibitor of CDK9, a cyclin-dependent kinase involved in transcriptional regulation and cancer progression. By targeting CDK9, ML380 disrupts RNA polymerase II-mediated transcription elongation, leading to downregulation of anti-apoptotic proteins like Mcl-1. It exhibits strong antiproliferative activity in cancer cells dependent on transcriptional addiction. ML380 has been utilized in preclinical studies to explore CDK9’s role in oncology and transcriptional control. This compound is valuable for researchers investigating transcriptional regulation, cancer therapeutics, and the development of selective CDK9-targeting agents. For research use only.
| CAS Number | 1627138-52-6 |
| Synonyms | N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide |
| Molecular Formula | C23H25F3N4O3S |
| Purity | ≥95% |
| IUPAC Name | N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide |
| InChI | InChI=1S/C23H25F3N4O3S/c1-2-29(15-17-5-3-4-6-20(17)23(24,25)26)22(31)16-9-11-30(12-10-16)34(32,33)19-7-8-21-18(13-19)14-27-28-21/h3-8,13-14,16H,2,9-12,15H2,1H3,(H,27,28) |
| InChIKey | FJPQEOQGIZSLES-UHFFFAOYSA-N |
| SMILES | CCN(CC1=CC=CC=C1C(F)(F)F)C(=O)C2CCN(CC2)S(=O)(=O)C3=CC4=C(C=C3)NN=C4 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
