ML359

• CAT Number: I032421
• CAS Number: 1069858-99-6
• Molecular Formula: C23H28ClNO4
• Molecular Weight: 417.93
• Purity: ≥95%
• Synonyms: ethyl 1-[(3-chloro-4-hydroxyphenyl)methyl]-4-(2-phenoxyethyl)piperidine-4-carboxylate
• InChI: InChI=1S/C23H28ClNO4/c1-2-28-22(27)23(12-15-29-19-6-4-3-5-7-19)10-13-25(14-11-23)17-18-8-9-21(26)20(24)16-18/h3-9,16,26H,2,10-15,17H2,1H3
• InChIKey: DCLHRRNJOZJGKD-UHFFFAOYSA-N
• SMILES: CCOC(=O)C1(CCN(CC1)CC2=CC(=C(C=C2)O)Cl)CCOC3=CC=CC=C3

ML359 (Cat No.: I032421) is a potent and selective small-molecule inhibitor of acyl-CoA:lysocardiolipin acyltransferase 1 (ALCAT1), an enzyme involved in remodeling cardiolipin within the inner mitochondrial membrane. By blocking ALCAT1 activity, ML359 helps preserve mitochondrial integrity, reduces oxidative stress, and improves cellular energy homeostasis. It has been widely used to study mitochondrial dysfunction in metabolic disorders, cardiovascular disease, and neurodegeneration. ML359 provides a valuable pharmacological tool for exploring the role of cardiolipin remodeling in disease progression and therapeutic intervention strategies.

Reference

[1]. Khodier C, et, al. Identification of ML359 as a Small Molecule Inhibitor of Protein Disulfide Isomerase. Probe Reports from the NIH Molecular Libraries Program. 2010-2013 Apr 12.
[Content Brief]

[2]. Bendapudi PK, et, al. ML359, a Small Molecule Inhibitor of Protein Disulfide Isomerase That Prevents Thrombus Formation and Inhibits Oxidoreductase but Not Transnitrosylase Activity. Blood (2014) 124 (21): 2880.