ML198

• CAT Number: I032414
• CAS Number: 1380716-06-2
• Molecular Formula: C17H14N4O
• Molecular Weight: 290.32
• Purity: ≥95%
• Synonyms: N-(4-ethynylphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carboxamide
• InChI: InChI=1S/C17H14N4O/c1-4-13-5-7-14(8-6-13)20-17(22)15-10-18-21-12(3)9-11(2)19-16(15)21/h1,5-10H,2-3H3,(H,20,22)
• InChIKey: HVZPJBKUFRREQC-UHFFFAOYSA-N
• SMILES: CC1=CC(=NC2=C(C=NN12)C(=O)NC3=CC=C(C=C3)C#C)C

ML198（Cat No.:I032414）is a potent, selective inhibitor of glucocerebrosidase (GCase), an enzyme critically involved in lysosomal glycosphingolipid metabolism. By specifically targeting GCase, ML198 elevates glucosylceramide levels, serving as a valuable research tool for studying Gaucher disease, a lysosomal storage disorder caused by GCase deficiency. Additionally, ML198 enables exploration of lysosomal dysfunction and autophagy-related pathways relevant in neurodegenerative disorders, particularly Parkinson’s disease. Its use aids researchers in understanding enzyme-substrate interactions, lipid metabolism disorders, and potential therapeutic strategies targeting the lysosomal pathway in metabolic and neurodegenerative diseases.