ML-60218

• CAT Number: I032429
• CAS Number: 577784-91-9
• Molecular Formula: C19H15Cl2N3O2S2
• Molecular Weight: 452.38
• Purity: ≥95%
• Synonyms: 2-chloro-N-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]benzenesulfonamide
• InChI: InChI=1S/C19H15Cl2N3O2S2/c1-11-13-9-12(20)7-8-16(13)27-19(11)15-10-18(24(2)22-15)23-28(25,26)17-6-4-3-5-14(17)21/h3-10,23H,1-2H3
• InChIKey: BVBDTTLISMIOJY-UHFFFAOYSA-N
• SMILES: CC1=C(SC2=C1C=C(C=C2)Cl)C3=NN(C(=C3)NS(=O)(=O)C4=CC=CC=C4Cl)C

ML-60218 (Cat No.: I032429) is a small-molecule inhibitor that targets RNA polymerase III, an enzyme responsible for transcribing small non-coding RNAs such as tRNAs and 5S rRNA. By blocking Pol III activity, ML-60218 interferes with protein synthesis and cellular growth, making it a valuable chemical probe in molecular biology and cancer research. It has been used to study the regulation of transcription and the role of Pol III–dependent pathways in tumorigenesis. ML-60218 highlights the potential of transcriptional inhibitors in therapeutic development.

Reference

[1]. Wu L, et al. Novel small-molecule inhibitors of RNA polymerase III. Eukaryot Cell. 2003;2(2):256-264.
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[2]. Yee NS, et al. Targeting developmental regulators of zebrafish exocrine pancreas as a therapeutic approach in human pancreatic cancer. Biol Open. 2012;1(4):295-307.
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[3]. Eichwald C, et al. Identification of a Small Molecule That Compromises the Structural Integrity of Viroplasms and Rotavirus Double-Layered Particles. J Virol. 2018;92(3):e01943-17. Published 2018 Jan 17.
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