MKK7-COV-9

• CAT Number: I014997
• CAS Number: 2283355-59-7
• Molecular Formula: C18H16N4O2
• Molecular Weight: 320.35
• Purity: ≥95%
• Synonyms: 3-(1H-indazol-3-yl)-N-methyl-5-(prop-2-enoylamino)benzamide
• InChI: InChI=1S/C18H16N4O2/c1-3-16(23)20-13-9-11(8-12(10-13)18(24)19-2)17-14-6-4-5-7-15(14)21-22-17/h3-10H,1H2,2H3,(H,19,24)(H,20,23)(H,21,22)
• InChIKey: OIVBYXJDKPKZFE-UHFFFAOYSA-N
• SMILES: CNC(=O)C1=CC(=CC(=C1)C2=NNC3=CC=CC=C32)NC(=O)C=C

MKK7-COV-9（Cat No.:I014997）is a covalent small-molecule inhibitor designed to selectively target mitogen-activated protein kinase kinase 7 (MKK7), a dual-specificity kinase within the JNK signaling pathway. By irreversibly binding to its catalytic domain, MKK7-COV-9 blocks phosphorylation events that drive stress responses, apoptosis, and inflammation. This compound is valuable for studying the regulation of JNK-mediated cellular processes, particularly in cancer biology, neurodegeneration, and inflammatory diseases. Its covalent binding mechanism provides sustained inhibition, making MKK7-COV-9 a powerful chemical probe for dissecting pathway dynamics and evaluating therapeutic potential.